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Application Note: Aragen's A Platform to Rapidly Purify and Formulate Immunoglobulins from Mammalian Expression Systems

Chromatography

Recently introduced technologies such as Protein A membrane devices and tangential flow filtration (TFF) systems capable of handling ultrafiltration and diafiltration of samples as low as 5 mL have significantly decreased the turnaround time.

This document is available upon request.

English (U.S.)

mage of Application Note for GORE™ Protein Capture Device Used in Manual LC Methods

Chromatography

The GORE Protein Capture Device with Protein A can be used as demonstrated in three different manual/semi-automated operations to rapidly purify monoclonal antibodies without an LC unit.

English (U.S.)

Image of Application Note for GORE™ Protein Capture Device Cleaning Protocols

Chromatography

Two cleaning protocols outlined in this application note potentially extend the lifetime of a GORE Protein Capture Device in the event that pressure elevates over the expected lifetime of the device.

English (U.S.)

Application Note: Energy Cost-Down Project: Reduction of Energy Usage at a Fermentation Plant

A cost-down project was completed in a fermentation plant. This project evaluated the effect of switching to new, lower-pressure-drop filters in the compressed air system that feeds their fermentation vessels.

English (U.S.)

Image of Application Note for GORE™ Protein Capture Device Used in Series

Chromatography

Two 3.5 mL GORE Protein Capture Devices can be connected in series, which doubles the column capacity by providing a 7.0 mL bed volume and allows capture of at least 200 mg of monoclonal antibody within 60 minutes.

English (U.S.)

Thumbnail image of Application Note

Chromatography

Boehringer-Ingelheim evaluated GORE Protein Capture Devices with Protein A vs. a traditional agarose bead column and found that, together with high titers, the GORE column can reduce overall process time and may help increase yields in monoclonal antibody purification by eliminating the need for additional downstream concentration steps.

English (U.S.)

Increasing the Productivity of mAb Purification using the GORE Protein Capture Devices with Protein A

Chromatography

Evaluate the impact of increasing operational flow rate steps (e.g. equilibrations, washes, and clean-in-place (CIP)) on the overall productivity (mg mAb/hour) of GORE Protein Capture Devices (PROA101 & PROA102).

English (U.S.)

Thumbnail image of Pharmaceutial Processing article reprint

Lyophilization

Article: Lyophilization: The Basics

Industry Articles, 540.88 KB,

Cherish Robinson, Product Specialist with Gore's PharmBIO business, discusses the advantages and disadvantages of freeze-drying bulk drug ingredients.

English (U.S.)

GORE Fermentation Air Filters Compliance Statements

Filtration Solutions for Life Sciences

Summary compliance statements are available upon request.

English (U.S.)

Customer Conversations About Our Field Trials: GORE<sup>®</sup> Fermentation Air Filters

Our customers share their thoughts about the performance of GORE Fermentation Air Filters and the experience of partnering with Gore. Contact us if you would like to initiate a field trial at your site.

English (U.S.)